Glutathione (GSH) is an antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals.
Coined “The Mother of all Antioxidants” and the “Master Cell Protector,” some say glutathione is the most important molecule in your body that you have never even heard of, so what is it and what does it do?
Glutathione can be synthesized in the liver from amino acids L-cysteine, L-glutamic acid and glycine however some people may not be capable of producing enough GSH. Poor diet, pollution, toxins, medications, stress, trauma, aging, infections and radiation all deplete your glutathione levels. When glutathione levels decrease, this is when the body becomes susceptible to disease.
High levels of GSH in the body and subsequently in tissues and blood serum have been shown to inhibit and prevent the replication of virtually all pathogens.
If you were to go 24 hours without food, your liver would steal amino acids from the protein in your muscles to make this critical compound. If you are not producing enough GSH then food supplementation is absolutely necessary.
Despite GSH’s water solubility, it is still poorly bioavailable. Powdered glutathione metabolism cleaves it into the three amino acids it is made up of (glycine, glutamine and cysteine.) This digestive cleaving process is so effective that nearly all of the glutathione stated on the original supplement label would never make it into circulation.
As a result of the poor bioavailability, the evidence for standard oral GSH as a means of improving glutathione status, reducing oxidative stress or for improving other markers of health, have been mixed and largely disappointing. In contrast, liposomal GSH has been shown to not only increase blood levels of GSH effectively and significantly but also increases the GSH to GSSG ratio, reduce other oxidative stress markers and improve markers of immune function in healthy adults to a significant degree.
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